Cities on the moon! That will be humanity's greatest achievement. Finally no longer bound to Earth – the moon as a springboard to the stars. The rockets are loaded with supplies and colonists, the robots programmed and ready for action. Everything has been planned down to the smallest detail, and there is absolutely no possibility of failure. Off to the moon!

Moon Colony Bloodbath is an engine-building tableau game – and at the same time an engine-losing game – with a common deck of cards that players build together. This ensures that many things happen: many of them bad and deadly for the people in your moon colony, some positive, and others that help you further expand your colony.

Specifically, in each round, a card is revealed from the common deck, which initially consists of four work cards, two problem cards, and two twist cards. With work cards, all players simultaneously perform an action of their choice: earn money through mining, produce food through agriculture, gain cards through research, construct a new building, or restock buildings with supplies. The twists differ from game to game. Problem cards add new event cards to the deck: hunger, paperwork, malfunctions, accidents, leaks, power outages – everything that can go wrong will go wrong. And every time the deck is shuffled, you must prepare yourselves anew for all these events.

Players can also add cards to the common deck themselves – either advantages that only help them or developments that affect all players.

The game ends either when there are no people left in a player's moon colony or when the players reach the end of the event deck. Then, the player with the most survivors wins.